Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770668 | 0.90 | GPBAR1 (0.40) | P2RX7HSD11B1GPBAR1NOTUMKDM4E | |
| SCHEMBL23770689 | 0.88 | ITGB2 (0.40) | HSD11B1GPBAR1PADI4NOTUMKDM4E | |
| SCHEMBL19970130 | 0.88 | ITGB2 (0.40) | HSD11B1GPBAR1PADI4NOTUMKDM4E | |
| SCHEMBL19970013 | 0.88 | ITGB2 (0.40) | HSD11B1GPBAR1PADI4NOTUMKDM4E | |
| SCHEMBL23770813 | 0.88 | ITGB2 (0.40) | P2RX7HSD11B1GPBAR1DGAT2NOTUM | |
| SCHEMBL23770485 | 0.88 | P2RX7 (0.38) | P2RX7HSD11B1GPBAR1DGAT2NOTUM | |
| SCHEMBL23770648 | 0.85 | GPBAR1 (0.41) | P2RX7HSD11B1GPBAR1ALKNOTUM | |
| SCHEMBL23770759 | 0.82 | MPL (0.43) | P2RX7GPBAR1NOTUMAKR1C3AKR1C1 | |
| SCHEMBL23770636 | 0.82 | DGAT1 (0.33) | — | |
| SCHEMBL23770488 | 0.79 | ITGB2 (0.40) | HSD11B1GPBAR1NOTUMKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |