Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770668 | 0.92 | GPBAR1 (0.40) | GPBAR1P2RX7KMT2AKDM4EMEN1 | |
| SCHEMBL23770656 | 0.85 | P2RX7 (0.39) | GPBAR1P2RX7KMT2AKDM4EMEN1 | |
| SCHEMBL23770813 | 0.85 | ITGB2 (0.40) | GPBAR1P2RX7KMT2AKDM4EMEN1 | |
| SCHEMBL23770837 | 0.84 | SMO (0.34) | KMT2AKDM4EMEN1ALDH1A1TSHR | |
| SCHEMBL23770485 | 0.84 | P2RX7 (0.38) | GPBAR1P2RX7KMT2AKDM4EMEN1 | |
| SCHEMBL23770785 | 0.83 | LMNA (0.43) | KMT2AKDM4EMEN1ALDH1A1HSD17B10 | |
| SCHEMBL23770844 | 0.82 | PTPN11 (0.33) | — | |
| SCHEMBL23770488 | 0.81 | ITGB2 (0.40) | GPBAR1KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL19970116 | 0.81 | DGAT1 (0.35) | — | |
| SCHEMBL23770659 | 0.80 | PTPN11 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |