Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770648 | 0.92 | GPBAR1 (0.41) | GPBAR1P2RX7KDM4EMEN1ALDH1A1 | |
| SCHEMBL23770656 | 0.90 | P2RX7 (0.39) | GPBAR1P2RX7KDM4EMEN1ALDH1A1 | |
| SCHEMBL23770813 | 0.90 | ITGB2 (0.40) | GPBAR1P2RX7KDM4EMEN1ALDH1A1 | |
| SCHEMBL23770485 | 0.89 | P2RX7 (0.38) | GPBAR1P2RX7KDM4EMEN1ALDH1A1 | |
| SCHEMBL23770488 | 0.88 | ITGB2 (0.40) | GPBAR1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL23770759 | 0.84 | MPL (0.43) | GPBAR1P2RX7NOTUMAKR1C3AKR1C1 | |
| SCHEMBL23770608 | 0.83 | NOTUM (0.41) | NOTUMMPL | |
| SCHEMBL23770893 | 0.82 | GPBAR1 (0.39) | GPBAR1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL19970115 | 0.81 | DGAT1 (0.34) | — | |
| SCHEMBL23770806 | 0.80 | RBP4 (0.36) | NOTUMSLC6A1MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |