Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 5/20 | 0.34 |
| ▸ | RAF1 | P04049 | 8/20 | 0.34 |
| ▸ | BRAF | P15056 | 8/20 | 0.34 |
| ▸ | ABL1 | P00519 | 7/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770583 | 0.87 | RAF1 (0.36) | SOS1RAF1BRAFABL1 | |
| SCHEMBL23770596 | 0.85 | ADRB1 (0.41) | SOS1RAF1BRAFABL1 | |
| SCHEMBL19925583 | 0.83 | SCN9A (0.37) | SOS1RAF1BRAFABL1 | |
| SCHEMBL23770773 | 0.81 | ABL1 (0.37) | ABL1 | |
| SCHEMBL23770701 | 0.78 | ATR (0.42) | RAF1BRAF | |
| SCHEMBL23770866 | 0.78 | SOS1 (0.34) | SOS1RAF1BRAF | |
| SCHEMBL23770607 | 0.75 | JAK2 (0.35) | ABL1 | |
| SCHEMBL19925208 | 0.75 | KIF18A (0.36) | SOS1RAF1BRAFABL1 | |
| SCHEMBL23770677 | 0.75 | ABL1 (0.36) | RAF1BRAFABL1 | |
| SCHEMBL23770587 | 0.73 | ABL1 (0.39) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |