Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | WNT3 | P56703 | 2/20 | 0.33 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770697 | 0.87 | CKS1B (0.41) | MAP4K4CKS1BSKP1SKP2MAPT | |
| SCHEMBL23770700 | 0.87 | HDAC6 (0.36) | SFRP1MCL1CKS1BSKP1SKP2 | |
| SCHEMBL29464470 | 0.85 | MCL1 (0.38) | EIF2AK4NR1H2NR1H3TGM2DPP4 | |
| SCHEMBL19927718 | 0.85 | MCL1 (0.38) | EIF2AK4NR1H2NR1H3TGM2DPP4 | |
| SCHEMBL29464410 | 0.85 | MCL1 (0.38) | EIF2AK4NR1H2NR1H3TGM2DPP4 | |
| SCHEMBL19925691 | 0.85 | MCL1 (0.38) | EIF2AK4NR1H2NR1H3TGM2DPP4 | |
| SCHEMBL23770806 | 0.84 | RBP4 (0.36) | TTR | |
| SCHEMBL23770608 | 0.83 | NOTUM (0.41) | TTR | |
| SCHEMBL23770488 | 0.82 | ITGB2 (0.40) | TTRMAPT | |
| SCHEMBL23770674 | 0.81 | MPL (0.38) | EIF2AK4TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |