Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP1 | P63208 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770612 | 0.90 | GPR119 (0.41) | CKS1BSKP1SKP2GPR119KIF18A | |
| SCHEMBL23770723 | 0.89 | PTPN11 (0.35) | MAPTLMNAPTPN11CNR2 | |
| SCHEMBL23770692 | 0.87 | EIF2AK4 (0.38) | CKS1BSKP1SKP2MAP4K4MAPT | |
| SCHEMBL23770700 | 0.87 | HDAC6 (0.36) | CKS1BSKP1SKP2GPR119SMARCA2 | |
| SCHEMBL23770859 | 0.85 | CYP1A2 (0.44) | HRH3CNR2 | |
| SCHEMBL23770433 | 0.85 | PDE10A (0.36) | CNR2 | |
| SCHEMBL23770664 | 0.84 | NPY5R (0.36) | ACHELMNACNR2 | |
| SCHEMBL29464343 | 0.83 | CKS1B (0.41) | CKS1BSKP1SKP2GPR119KIF18A | |
| SCHEMBL19925175 | 0.83 | CKS1B (0.41) | CKS1BSKP1SKP2GPR119KIF18A | |
| SCHEMBL23770653 | 0.82 | CNR2 (0.40) | MAPTLMNACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |