Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770776 | 0.87 | ABL1 (0.38) | AGPAT2ABL1CCNT1CDK9 | |
| SCHEMBL23770695 | 0.83 | CYP1A2 (0.34) | NOS3NOS2ALDH1A1DYRK1ACCNT1 | |
| SCHEMBL23770430 | 0.82 | ABL1 (0.33) | JAK2ABL1CCNT1CDK9 | |
| SCHEMBL23770707 | 0.81 | AGPAT2 (0.39) | AGPAT2LMNAALDH1A1GLAL3MBTL1 | |
| SCHEMBL23770613 | 0.81 | CYP1A2 (0.37) | LMNAALDH1A1GLAS1PR1 | |
| SCHEMBL23770773 | 0.79 | ABL1 (0.37) | NOS3NOS2AGPAT2ABL1S1PR1 | |
| SCHEMBL23770552 | 0.79 | JAK2 (0.33) | NOS3NOS2JAK2DYRK1ACCNT1 | |
| SCHEMBL19927741 | 0.79 | SCN9A (0.49) | LMNAALDH1A1GLAL3MBTL1SCN9A | |
| SCHEMBL29464375 | 0.79 | SCN9A (0.49) | LMNAALDH1A1GLAL3MBTL1SCN9A | |
| SCHEMBL23770544 | 0.76 | S1PR1 (0.33) | ABL1S1PR1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |