Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.33 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770544 | 0.87 | S1PR1 (0.33) | ABL1S1PR1 | |
| SCHEMBL23770776 | 0.86 | ABL1 (0.38) | ABL1EPHA4AGPAT2MAPK13MAPK12 | |
| SCHEMBL23770543 | 0.83 | S1PR1 (0.35) | S1PR1NOS3NOS2 | |
| SCHEMBL23770596 | 0.82 | ADRB1 (0.41) | ABL1 | |
| SCHEMBL23770583 | 0.82 | RAF1 (0.36) | ABL1 | |
| SCHEMBL23770447 | 0.81 | SOS1 (0.34) | ABL1 | |
| SCHEMBL23770566 | 0.81 | AGPAT2 (0.35) | ABL1EPHA4AGPAT2TRPA1 | |
| SCHEMBL23770732 | 0.79 | NOS3 (0.38) | ABL1S1PR1AGPAT2NOS3NOS2 | |
| SCHEMBL19925174 | 0.78 | SCN9A (0.40) | ABL1 | |
| SCHEMBL29464306 | 0.78 | SCN9A (0.40) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |