Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770695 | 0.89 | CYP1A2 (0.34) | DYRK1AKDM4EMEN1NOS3NOS1 | |
| SCHEMBL23770543 | 0.83 | S1PR1 (0.35) | KDM4EMEN1NOS3NOS1NOS2 | |
| SCHEMBL23770438 | 0.82 | KDM4E (0.34) | KDM4ENOS3NOS2SRCFGFR1 | |
| SCHEMBL23770776 | 0.81 | ABL1 (0.38) | CCNT1CDK9 | |
| SCHEMBL23770407 | 0.80 | ADORA2A (0.35) | DYRK1AKDM4ECCNT1CDK9 | |
| SCHEMBL23770625 | 0.80 | NOS3 (0.39) | KDM4ENOS3NOS1NOS2 | |
| SCHEMBL23770430 | 0.79 | ABL1 (0.33) | JAK2TYK2CCNT1CDK9 | |
| SCHEMBL23770732 | 0.79 | NOS3 (0.38) | JAK2DYRK1ANOS3NOS2CCNT1 | |
| SCHEMBL23770602 | 0.78 | NOS3 (0.33) | NOS3NOS2 | |
| SCHEMBL23770406 | 0.75 | NOS3 (0.30) | NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |