Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.30 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770598 | 0.84 | ADRB2 (0.43) | PTPN11 | |
| SCHEMBL23770480 | 0.83 | GRIN2B (0.33) | — | |
| SCHEMBL19968848 | 0.79 | KIF18A (0.37) | HSD11B1KRASPTPN11SOS1P2RY1 | |
| SCHEMBL23770818 | 0.78 | — | — | |
| SCHEMBL23770787 | 0.78 | PDE10A (0.35) | — | |
| SCHEMBL23770749 | 0.78 | MPL (0.33) | SOS1 | |
| SCHEMBL23770416 | 0.77 | PTPN11 (0.37) | PTPN11 | |
| SCHEMBL23770621 | 0.77 | PDE10A (0.35) | — | |
| SCHEMBL23770817 | 0.77 | — | — | |
| SCHEMBL23770748 | 0.76 | RORC (0.33) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |