Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770744 | 0.85 | RAF1 (0.33) | MPLHCRTR1HCRTR2GRIN2BSOS1 | |
| SCHEMBL23770830 | 0.85 | MAP4K1 (0.33) | MPLHCRTR1HCRTR2GRIN2BSOS1 | |
| SCHEMBL23770733 | 0.82 | PDE10A (0.32) | HSD17B10HCRTR1HCRTR2PDE10AGRIN2B | |
| SCHEMBL23770480 | 0.79 | GRIN2B (0.33) | GRIN2B | |
| SCHEMBL23770787 | 0.79 | PDE10A (0.35) | CYP1A2CYP2C9KDM4EALDH1A1CYP3A4 | |
| SCHEMBL23770621 | 0.79 | PDE10A (0.35) | CYP1A2CYP2C9KDM4EALDH1A1CYP3A4 | |
| SCHEMBL23770649 | 0.78 | PIM1 (0.34) | CYP1A2CYP2D6TSHRPRKCQTTR | |
| SCHEMBL23770812 | 0.78 | HSD11B1 (0.30) | SOS1 | |
| SCHEMBL19968850 | 0.77 | SCN9A (0.37) | MPLCYP1A2CYP2C9KDM4EALDH1A1 | |
| SCHEMBL29464535 | 0.77 | SCN9A (0.37) | MPLCYP1A2CYP2C9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |