Sugi Predict

Sugi Predict / Compounds / SCHEMBL237723

SCHEMBL237723

SCHEMBL237723

Oc1ccccc1C12CC3CC(C1)CC(c1ccccc1O)(C3)C2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIN2D O15399 1/20 0.43
▸ GRIN3B O60391 1/20 0.43
▸ GRIN1 Q05586 1/20 0.43
▸ GRIN2A Q12879 1/20 0.43
▸ GRIN2B Q13224 1/20 0.43
▸ GRIN2C Q14957 1/20 0.43
▸ GRIN3A Q8TCU5 1/20 0.43
▸ MEN1 O00255 3/20 0.42
▸ KMT2A Q03164 3/20 0.42
▸ POLB P06746 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ GFER P55789 1/20 0.42
▸ ALDH1A1 P00352 4/20 0.39
▸ KDM4E B2RXH2 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ ALOX12 P18054 2/20 0.39
▸ HSD17B10 Q99714 2/20 0.39
▸ TSHR P16473 1/20 0.39
▸ HTT P42858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29809124 0.88 MEN1 (0.48) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL345587 0.88 MEN1 (0.48) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL3757968 0.85 KMT2A (0.40) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL12804771 0.84 KDM4E (0.39) MEN1KMT2APOLBGAAGFER
SCHEMBL3752409 0.80 MEN1 (0.44) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL3049402 0.80 ALOX5AP (0.37) MEN1KMT2APOLBGAAGFER
SCHEMBL13004821 0.79 IDO1 (0.43) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL2426368 0.78 KMT2A (0.43) MEN1KMT2APOLBGAAGFER
SCHEMBL3749653 0.78 MEN1 (0.47) MEN1KMT2APOLBGAAGFER
SCHEMBL3757853 0.76 KMT2A (0.44) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1336597-B1 Hydroxyphenyl adamantanes and process for the production of the same HONSHU CHEMICAL IND (JP) 2008-07-16 — — EP claimed
US-6720460-B2 FORMING HEAT RESISTANT, MECHANICAL STRENGTH POLYMER ADDITIVES; ACID CATALYZED REACTION OF ADAMANTANE DIOL OR TRIOL WITH PHENOLIC DERIVATIVE HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2004-04-13 — — US claimed
US-20030187307-A1 Hydroxyphenyl adamantanes and process for the production of the same HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2003-10-02 — — US claimed
EP-1336597-A1 Hydroxyphenyl adamantanes and process for the production of the same Honshu Chemical Industry Co., Ltd. (JP) 2003-08-20 — — EP claimed
US-6497895-B2 TRANSDERMAL PATCH RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2002-12-24 — — US claimed
US-6365146-B1 POLYAMIDEESTER COPOLYMER RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2002-04-02 — — US claimed
US-20220079936-A1 MULTI-ARM POLYMER PRODRUGS NEKTAR THERAPEUTICS (US) 2022-03-17 — — US disclosed
CN-114072461-A Thermoplastic resin composition, molded article, and product 三菱电机株式会社 2022-02-18 — — CN disclosed
US-10463659-B2 Multi-arm polymer prodrugs NEKTAR THERAPEUTICS (US) 2019-11-05 — — US disclosed
EP-1756173-B1 METHOD OF PREPARING PROPIONIC ACID-TERMINATED POLYMERS NEKTAR THERAPEUTICS (US) 2019-04-03 — — EP disclosed
US-20180021444-A1 MULTI-ARM POLYMER PRODRUGS NEKTAR THERAPEUTICS 2018-01-25 — — US disclosed
US-9808533-B2 Multi-arm polymer prodrugs NEKTAR THERAPEUTICS (US) 2017-11-07 — — US disclosed
EP-1675622-B1 MULTI-ARM POLYMER PRODRUGS NEKTAR THERAPEUTICS (US) 2017-06-14 — — EP disclosed
US-20030187307-A1 Hydroxyphenyl adamantanes and process for the production of the same HONSHU CHEMICAL INDUSTRY CO., LTD. (JP) 2003-10-02 — — US disclosed
US-20030170202-A1 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2003-09-11 — — US disclosed
EP-1336597-A1 Hydroxyphenyl adamantanes and process for the production of the same Honshu Chemical Industry Co., Ltd. (JP) 2003-08-20 — — EP disclosed
US-6497895-B2 TRANSDERMAL PATCH RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2002-12-24 — — US disclosed
US-6365146-B1 POLYAMIDEESTER COPOLYMER RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2002-04-02 — — US disclosed
US-20020035217-A1 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2002-03-21 — — US disclosed
US-6328988-B1 DRUGS AND COSMETICS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2001-12-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10463659-B2 Multi-arm polymer prodrugs PAICS, CD38, ENTPD1 GRIN2D 4743/4885GRIN3B 4243/4885GRIN1 4567/4885
US-20030187307-A1 Hydroxyphenyl adamantanes and process for the production of the same CYP8B1, DHPS, P4HA1 GRIN2D 2144/4885GRIN3B 1913/4885GRIN1 558/4885
US-20180021444-A1 MULTI-ARM POLYMER PRODRUGS PAICS, CD38, ENTPD1 GRIN2D 4743/4885GRIN3B 4243/4885GRIN1 4567/4885
US-20030170202-A1 Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules LIPA, ABHD16A, CHMP4B GRIN2D 4495/4885GRIN3B 3288/4885GRIN1 3586/4885
US-20220079936-A1 MULTI-ARM POLYMER PRODRUGS PAICS, CD38, ENTPD1 GRIN2D 4743/4885GRIN3B 4243/4885GRIN1 4567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.