Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23071351 | 0.77 | ALDH1A1 (0.36) | LMNAALDH1A1MEN1POLBGAA | |
| SCHEMBL7834287 | 0.76 | HSD11B1 (0.36) | LMNAALDH1A1MEN1POLBGAA | |
| SCHEMBL9509354 | 0.72 | LMNA (0.34) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2746867 | 0.69 | EPHX2 (0.36) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL458991 | 0.69 | HTR2C (0.34) | — | |
| SCHEMBL32685217 | 0.67 | GRIN2D (0.42) | LMNAALDH1A1MEN1POLBGAA | |
| SCHEMBL9586481 | 0.66 | HTR2C (0.31) | — | |
| SCHEMBL1264419 | 0.66 | ALDH1A1 (0.38) | LMNAALDH1A1MEN1POLBGAA | |
| SCHEMBL16958502 | 0.66 | HTR2C (0.31) | — | |
| SCHEMBL2746865 | 0.66 | KDM4E (0.32) | LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588480-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF& xA; | SANOFI (FR) | 2013-05-08 | — | — | EP | disclosed |
| WO-2011161537-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-29 | — | — | WO | disclosed |