Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Suprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.94 |
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 0.94 |
| ▸ | HPGD | P15428 | 6/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.94 |
| ▸ | HPGDS | O60760 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-Suprofen SCHEMBL1122667 | 0.97 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| (S)-Suprofen SCHEMBL5102821 | 0.97 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| Suprofen SCHEMBL23792 | 0.97 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| Suprofen SCHEMBL9621599 | 0.95 | PTGS2 (0.97) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| Suprofen SCHEMBL3262801 | 0.94 | PTGS2 (0.94) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| Suprofen SCHEMBL11706680 | 0.93 | PTGS2 (0.82) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| SCHEMBL12286991 | 0.88 | HPGD (0.83) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| Suprofen SCHEMBL3971317 | 0.86 | PTGS1 (0.74) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| SCHEMBL14213389 | 0.85 | HPGD (0.78) | PTGS2HPGDPTGS1CYP2C9LMNA | |
| SCHEMBL11704028 | 0.84 | PTGS1 (0.72) | PTGS2HPGDPTGS1CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065047-A1 | Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein | Board of Regents, The University of Texas System (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1214940-B1 | Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein | UNIV TEXAS (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1214940-A1 | Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-0805684-B1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 2002-06-12 | — | — | EP | disclosed |
| US-5955451-A | NONSTEROID ANTIINFLAMMATORY AGENTS COMPLEXED WITH ZWITTERIONS OR PHOSPHOLIPIDS FOR NONIRRITATION OF GASTROINTESTINAL SYSTEMS AND ANTIPYRETICS | THE UNIVERSITY OF TEXAS SYSTEM BOARD OF REGENTS | 1999-09-21 | — | — | US | disclosed |
| WO-1998013073-A9 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | — | 1998-08-06 | — | — | WO | disclosed |
| EP-0805684-A4 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5763422-A | Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1998013073-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-04-02 | — | — | WO | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |