Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Suprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 0.94 |
| ▸ | PTGS1 known ✓ | P23219 | 7/20 | 0.94 |
| ▸ | HPGD | P15428 | 7/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.94 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.94 |
| ▸ | HPGDS | O60760 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Suprofen SCHEMBL23792 | 0.97 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| (S)-Suprofen SCHEMBL5102821 | 0.97 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| (R)-Suprofen SCHEMBL1122667 | 0.97 | PTGS2 (1.00) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL9621599 | 0.95 | PTGS2 (0.97) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL3971318 | 0.94 | PTGS2 (0.94) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| SCHEMBL12286991 | 0.88 | HPGD (0.83) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL11706680 | 0.88 | PTGS2 (0.82) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| SCHEMBL14213389 | 0.85 | HPGD (0.78) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| Suprofen SCHEMBL3971317 | 0.84 | PTGS1 (0.74) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 | |
| SCHEMBL3805719 | 0.84 | HPGD (0.76) | PTGS2HPGDPTGS1CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086071-A1 | SPECTRALLY ENCODED CONSUMABLE SPECTROMETER APPARATUS AND METHODS | NUEOU, INC. (US) | 2016-06-02 | — | — | WO | disclosed |
| WO-2010007337-A1 | IMPROVEMENTS IN LAVATORY DISPENSING DEVICES | RECKITT BENCKISER INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| EP-0652489-B1 | Process for processing a photosensitive lithographic printing plate requiring no fountain solution | FUJI PHOTO FILM CO LTD (JP) | 1997-11-05 | — | — | EP | disclosed |
| EP-0652489-A1 | Process for processing a photosensitive lithographic printing plate requiring no fountain solution | FUJI PHOTO FILM CO., LTD. (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5132706-A | TRANSFERRING INK WITH AN ADHESIVE CHARACTERISTIC CHANGED BY APPLIED VOLTAGE AND REPLACING COMPONENT LOSS OF INK IN RESPONSE TO DETERMINED CHANGES OF INK | CANON KABUSHIKI KAISHA (JP) | 1992-07-21 | — | — | US | disclosed |
| EP-0392826-A2 | Image forming method and image forming apparatus | CANON KABUSHIKI KAISHA (JP) | 1990-10-17 | — | — | EP | disclosed |
| US-4085182-A | MELT EXTRUSION, POLYCAPROLACTAM, CARBON BLACK | TEIJIN LIMITED (JA) | 1978-04-18 | — | — | US | disclosed |