Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Suprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 7/20 | 0.74 |
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.74 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.74 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Suprofen SCHEMBL3971318 | 0.86 | PTGS2 (0.94) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| Suprofen SCHEMBL23792 | 0.86 | PTGS2 (1.00) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| (R)-Suprofen SCHEMBL1122667 | 0.86 | PTGS2 (1.00) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| (S)-Suprofen SCHEMBL5102821 | 0.86 | PTGS2 (1.00) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| Suprofen SCHEMBL9621599 | 0.85 | PTGS2 (0.97) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| Suprofen SCHEMBL3262801 | 0.84 | PTGS2 (0.94) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| SCHEMBL11449716 | 0.84 | HPGDS (0.62) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| Suprofen SCHEMBL11706680 | 0.81 | PTGS2 (0.82) | PTGS1PTGS2HPGDCYP2C9LMNA | |
| Phenyl Propionic Acid SCHEMBL23581098 | 0.79 | KEAP1 (0.66) | PTGS1PTGS2CYP2C9LMNAALDH1A1 | |
| Phenyl Propionic Acid SCHEMBL8935146 | 0.79 | KEAP1 (0.66) | PTGS1PTGS2CYP2C9LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065047-A1 | Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein | Board of Regents, The University of Texas System (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1214940-B1 | Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein | UNIV TEXAS (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1214940-A1 | Methods of enhancing the therapeutic activity of NSAIDs and compositions of zwitterionic phospholipids useful therein | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-0805684-B1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 2002-06-12 | — | — | EP | disclosed |
| US-5955451-A | NONSTEROID ANTIINFLAMMATORY AGENTS COMPLEXED WITH ZWITTERIONS OR PHOSPHOLIPIDS FOR NONIRRITATION OF GASTROINTESTINAL SYSTEMS AND ANTIPYRETICS | THE UNIVERSITY OF TEXAS SYSTEM BOARD OF REGENTS | 1999-09-21 | — | — | US | disclosed |
| WO-1998013073-A9 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | — | 1998-08-06 | — | — | WO | disclosed |
| EP-0805684-A4 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | UNIV TEXAS (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5763422-A | Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1998013073-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDs AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1998-04-02 | — | — | WO | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |
| US-4528193-A | Inflammation-preventing pharmaceutical composition of oral administration | A. NATTERMAN & CIE. GMBH (DE) | 1985-07-09 | — | — | US | disclosed |
| US-4421747-A | PHOSPHOLIPID AND DERIVATIVE OF PHENYLACETIC OR PHENYLPROPIONIC ACID | A. NATTERMANN & CIE. GMBH (DE) | 1983-12-20 | — | — | US | disclosed |
| US-4378354-A | CONSISTING OF A PHOSPHOLIPID AND SALICYLIC ACID OR DERIVATIVE | A. NATTERMANN & CIE. GMBH (DE) | 1983-03-29 | — | — | US | disclosed |
| US-4369182-A | Inflammation-preventing pharmaceutical composition of oral administration | A. NATTERMANN & CIE GMBH (DE) | 1983-01-18 | — | — | US | disclosed |
| US-4332795-A | INDOLE COMPOUND AND PHOSPHOLIPID | A. NATTERMANN & CIE. GMBH (DE) | 1982-06-01 | — | — | US | disclosed |