Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 8/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TARDBP | Q13148 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2380516 | 1.00 | CA12 (0.64) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL22140609 | 0.89 | CA12 (0.64) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL13834757 | 0.88 | CA12 (0.74) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL2379548 | 0.87 | CA12 (0.65) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL5066331 | 0.87 | CA12 (0.65) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL2378787 | 0.87 | CA12 (0.65) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL2381388 | 0.86 | CA12 (0.67) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL2381206 | 0.86 | CA12 (0.67) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL7843204 | 0.86 | CA12 (0.67) | CA12CA9ACHEHSD17B10KMT2A | |
| SCHEMBL12898412 | 0.86 | ACHE (0.60) | CA12CA9ACHEHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364304-A1 | Alpha-lipoic acid derivatives and their use in drug preparation | ISTITUTO BIOCHIMICO NAZIONALE SAVIO s.r.l. (IT) | 2011-09-14 | — | — | EP | disclosed |
| US-20110212954-A1 | ALPHA-LIPOIC ACID DERIVATIVES AND THEIR USE IN DRUG PREPARATION | ISTITUTO BIOCHIMICO NAZIONALE SAVIO S.R.L. (IT) | 2011-09-01 | — | — | US | disclosed |
| US-20110212954-A1 | ALPHA-LIPOIC ACID DERIVATIVES AND THEIR USE IN DRUG PREPARATION | ISTITUTO BIOCHIMICO NAZIONALE SAVIO S.R.L. (IT) | 2011-09-01 | — | — | US | disclosed |
| WO-2010052310-A1 | ALPHA-LIPOIC ACID DERIVATIVES AND THEIR USE IN DRUG PREPARATION | SEGIX ITALIA S.R.L. (IT) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052310-A1 | ALPHA-LIPOIC ACID DERIVATIVES AND THEIR USE IN DRUG PREPARATION | SEGIX ITALIA S.R.L. (IT) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212954-A1 | ALPHA-LIPOIC ACID DERIVATIVES AND THEIR USE IN DRUG PREPARATION | ALOX12, ALOX15, ALOX15B | CA12 2077/4885CA9 1117/4885ACHE 1990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.