Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379988 | 0.79 | GPR84 (0.41) | GAAGPR84CHEK1NR4A2PSMB8 | |
| SCHEMBL1850720 | 0.79 | GPR84 (0.41) | GPR84PARP1ALDH1A1 | |
| SCHEMBL2074196 | 0.76 | IMPDH2 (0.41) | GAAALDH1A1MGAMSIMGAM2 | |
| SCHEMBL2073636 | 0.76 | FFAR1 (0.39) | GAAGPR84PARP1FEN1SLC6A4 | |
| SCHEMBL7459887 | 0.76 | GPR84 (0.39) | GAAGPR84CHEK1NR4A2PSMB8 | |
| SCHEMBL2072979 | 0.73 | ABCG2 (0.42) | GAAPARP1ALDH1A1 | |
| SCHEMBL2070937 | 0.73 | KIF11 (0.40) | ALDH1A1 | |
| SCHEMBL3381547 | 0.72 | GPR84 (0.39) | GAAGPR84PARP1MGAMSI | |
| SCHEMBL19283769 | 0.72 | MAP2K1 (0.44) | GAACHEK1SLC6A4ALDH1A1DYRK1A | |
| SCHEMBL10846060 | 0.70 | KDM4E (0.46) | GAANR4A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |