Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299924 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL577429 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL8199316 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL22003 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL7052601 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL5033222 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL2373879 | 1.00 | HIF1A (1.00) | — | |
| Piperazine SCHEMBL734764 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL3999265 | 1.00 | HIF1A (1.00) | — | |
| SCHEMBL576335 | 1.00 | HIF1A (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 759491 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6352782-B1 | — | — | None | — | — | US | claimed |
| US-6384031-B1 | — | — | None | — | — | US | claimed |
| US-9975864-B2 | Preparation of cobicistat intermediates | MYLAN LABORATORIES LIMITED (IN) | 2018-05-22 | — | — | US | claimed |
| US-9975904-B2 | Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes | ONO PHARMACEUTICAL CO., LTD. (JP) | 2018-05-22 | — | — | US | claimed |
| US-9976390-B2 | Drilling fluids with leakoff control and drill cuttings removal sweeps | BAKER HUGHES, A GE COMPANY, LLC (US) | 2018-05-22 | — | — | US | claimed |
| US-9976077-B2 | Photochromic articles containing polyoxometalate derivatives and methods of making same | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-05-22 | — | — | US | claimed |
| US-9975081-B2 | Method for purifying gas using liquid marbles | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-05-22 | — | — | US | claimed |
| US-9976076-B2 | Photochromic articles containing a polyoxometalate and methods of making same | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-05-22 | — | — | US | claimed |
| US-20180134692-A1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. | 2018-05-17 | — | — | US | claimed |
| US-20180134909-A1 | PREPARATION OF HIGH CONDUCTIVITY COPPER FILMS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2018-05-17 | — | — | US | claimed |
| US-3935214-A | ANTICOAGULANT | DONAU-PHARMAZIE GESELLSCHAFT M.B.H. (OE) | 1976-01-27 | — | — | US | claimed |
| US-3933783-A | Formation of peptide bonds in the presence of isonitriles | AJINOMOTO CO., INC. (JA) | 1976-01-20 | — | — | US | claimed |
| US-3934017-A | Anthelmintic composition and method utilizing isothiocyanobenzazoles active ingredients | CIBA-GEIGY CORPORATION (US) | 1976-01-20 | — | — | US | claimed |
| US-3933829-A | 4-Aminoquinoline derivatives | JOHN WYETH & BROTHER LIMITED (EN) | 1976-01-20 | — | — | US | claimed |
| US-3933803-A | ANTIBACTERIAL, ANTIMITOTIC, ANTIMYCOTIC | INSTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1976-01-20 | — | — | US | claimed |
| US-3933825-A | SURFACTANTS, FOAMING AGENTS | BRISTOL-MYERS COMPANY (US) | 1976-01-20 | — | — | US | claimed |
| US-3932539-A | Process for preparing unsaturated terpene alcohols | SCM CORPORATION (US) | 1976-01-13 | — | — | US | claimed |
| US-3932426-A | 3-[1-Hydroxy-2-(3- or 4-hydroxypiperidino)ethyl]-5-phenylisoxazole | SHIONOGI & CO., LTD. (JA) | 1976-01-13 | — | — | US | claimed |
| US-3931216-A | Process for the manufacture of 2-arylamino-2-imidazoline derivatives and their salts | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | claimed |
| US-3931270-A | Process for producing 2-thia substituted 1,4 diones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1976-01-06 | — | — | US | claimed |