Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28656112 | 0.86 | CA12 (0.49) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL28206684 | 0.82 | CA12 (0.49) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL16372412 | 0.81 | MTNR1A (0.46) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL19500875 | 0.80 | CA12 (0.47) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL18114479 | 0.78 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL668237 | 0.77 | KDM4E (0.62) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| Methyl 3,4-Methylenedioxybenzoate SCHEMBL133049 | 0.77 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL24735705 | 0.77 | CA12 (0.46) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL30278282 | 0.77 | CA12 (0.46) | NPC1RAB9ASMN1; SMN2CASP3SENP7 | |
| SCHEMBL15865437 | 0.75 | MTNR1A (0.52) | NPC1RAB9ASMN1; SMN2CASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | NPC1 2467/4885RAB9A 2887/4885SMN1; SMN2 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.