Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 5/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11182 | 0.81 | PRMT5 (0.42) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL17677977 | 0.81 | PDPK1 (0.46) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL15333263 | 0.80 | LPL (0.44) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL21025741 | 0.80 | PRMT5 (0.41) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL23165855 | 0.78 | YTHDC1 (0.52) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL29850421 | 0.78 | YTHDC1 (0.52) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL22408428 | 0.78 | CSF1R (0.40) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL15288236 | 0.78 | PRMT5 (0.40) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL16440186 | 0.76 | PRMT5 (0.39) | PRMT5WDR77CA12CA1CA2 | |
| SCHEMBL19896283 | 0.74 | LPL (0.46) | PRMT5WDR77CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987275-B2 | Indazole compounds and their uses | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-8987275-B2 | Indazole compounds and their uses | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130184287-A1 | INDAZOLE COMPOUNDS AND THEIR USES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130184287-A1 | INDAZOLE COMPOUNDS AND THEIR USES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| EP-2547661-A2 | INDAZOLE COMPOUNDS AND THEIR USES | Dana-Farber Cancer Institute, Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115725-A2 | INDAZOLE COMPOUNDS AND THEIR USES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011115725-A2 | INDAZOLE COMPOUNDS AND THEIR USES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184287-A1 | INDAZOLE COMPOUNDS AND THEIR USES | OAT, CYP3A43, CYP11B2 | PRMT5 1847/4885WDR77 3869/4885CA12 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.