Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.55 |
| ▸ | EIF4A3 | P38919 | 4/20 | 0.43 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GRK3 | P35626 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16806087 | 0.79 | IDO1 (0.53) | METAP2DHODHIDO1KDM4ETDO2 | |
| SCHEMBL20884905 | 0.76 | METAP2 (0.59) | METAP2CLK2GSK3AGSK3BCDK7 | |
| SCHEMBL2595232 | 0.76 | METAP2 (0.51) | METAP2 | |
| SCHEMBL459215 | 0.76 | TDO2 (0.54) | METAP2DHODHIDO1TDO2 | |
| SCHEMBL16804164 | 0.75 | DHPS (0.42) | METAP2IDO1TDO2 | |
| SCHEMBL23338155 | 0.75 | METAP2 (0.58) | METAP2FABP3FABP4IDO1KDM4E | |
| SCHEMBL20883605 | 0.73 | METAP2 (0.56) | METAP2EIF4A3IDO1KDM4EMEN1 | |
| SCHEMBL681814 | 0.73 | METAP2 (0.56) | METAP2EIF4A3CDK2IDO1KDM4E | |
| SCHEMBL27973115 | 0.73 | PRKAB2 (0.47) | EIF4A3DHODHFABP3FABP4PRKAB2 | |
| SCHEMBL5446859 | 0.72 | METAP2 (0.55) | METAP2MAPK1IDO1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | METAP2 2421/4885EIF4A3 3448/4885DHODH 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.