Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 3/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15687391 | 0.84 | NR4A2 (0.41) | SSTR4ALDH1A1GAAADORA3ADORA1 | |
| SCHEMBL28932406 | 0.78 | TSHR (0.41) | DHODHALDH1A1FABP4NR4A1NR4A2 | |
| SCHEMBL23809394 | 0.76 | MAPK13 (0.43) | ALDH1A1GAAADORA1LMNATSHR | |
| SCHEMBL19954876 | 0.76 | SSTR4 (0.50) | SSTR4ADORA3ADORA1LMNASMN1; SMN2 | |
| SCHEMBL31582863 | 0.74 | ADORA3 (0.40) | SSTR4ADORA3ADORA1LMNASMN1; SMN2 | |
| SCHEMBL23979724 | 0.74 | ADORA3 (0.40) | SSTR4ADORA3ADORA1LMNASMN1; SMN2 | |
| SCHEMBL31632929 | 0.72 | MYC (0.49) | DHODHALDH1A1FABP4TSHRMYC | |
| SCHEMBL31632943 | 0.71 | ALB (0.44) | DHODHALDH1A1GAASMN1; SMN2TSHR | |
| SCHEMBL70779 | 0.71 | NR4A1 (0.50) | DHODHALDH1A1FABP4NR4A1NR4A2 | |
| SCHEMBL23809338 | 0.71 | FABP4 (0.40) | DHODHFABP4NR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | DHODH 3826/4885SSTR4 4805/4885ALDH1A1 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.