Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5998389 | 0.87 | MAPK13 (0.42) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL26581194 | 0.80 | TP53 (0.41) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL27988705 | 0.76 | HSD17B10 (0.38) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL23809387 | 0.76 | DHODH (0.42) | ALDH1A1KDM4ELMNAPPARAPPARG | |
| SCHEMBL28450698 | 0.72 | ALDH1A1 (0.41) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL21849158 | 0.72 | MAPT (0.51) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL23809360 | 0.71 | KDM4E (0.40) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL5473230 | 0.69 | GFER (0.47) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL8320853 | 0.67 | NAMPT (0.40) | MAPK13EIF2AK2MAPK12MAPK11MAPK14 | |
| SCHEMBL13806534 | 0.67 | MMP2 (0.44) | ALDH1A1KDM4ELMNAKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | MAPK13 2293/4885EIF2AK2 456/4885MAPK12 2086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.