Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15517124 | 0.85 | ELANE (0.41) | NAMPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL23563223 | 0.82 | KDM4E (0.39) | ALDH1A1KDM4EMEN1KMT2AMAPK13 | |
| SCHEMBL28361133 | 0.82 | ALDH1A1 (0.51) | ALDH1A1KDM4EMEN1KMT2AMAPK13 | |
| SCHEMBL23809325 | 0.81 | KDM4E (0.38) | ALDH1A1KDM4EMEN1KMT2AMAPK13 | |
| SCHEMBL21816286 | 0.80 | MAPT (0.55) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL31429464 | 0.75 | HTR3A (0.41) | MEN1KMT2AMAPTRARGRORC | |
| SCHEMBL12536276 | 0.74 | MAPK13 (0.42) | NAMPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL28809240 | 0.74 | KDM4E (0.33) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL31729301 | 0.74 | KDM4E (0.33) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL31123882 | 0.74 | KDM4E (0.33) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| US-5955470-A | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0517984-A1 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0518767-A2 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | NAMPT 3421/4885ALDH1A1 2556/4885KDM4E 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.