Imidaclothiz

Imidaclothiz

SCHEMBL238122

O=[N+]([O-])N=C1NCCN1Cc1cnc(Cl)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.55
CHRNA4 P43681 1/20 0.55
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
LMNA P02545 4/20 0.36
KMT2A Q03164 2/20 0.36
MAPT P10636 2/20 0.36
RECQL P46063 1/20 0.36
GAA P10253 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.35
CHRNA1 P02708 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA7 P36544 1/20 0.35
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Imidaclothiz SCHEMBL676082 1.00 CHRNB2 (0.55) CHRNB2CHRNA4ALDH1A1SMN1; SMN2LMNA
SCHEMBL7982213 0.93 CHRNB2 (0.48) CHRNB2CHRNA4ALDH1A1SMN1; SMN2LMNA
SCHEMBL237765 0.89 CHRNB2 (0.49) CHRNB2CHRNA4ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL234983 0.88 CHRNB2 (0.50) CHRNB2CHRNA4ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL9069332 0.87 CHRNB2 (0.49) CHRNB2CHRNA4ALDH1A1SMN1; SMN2KMT2A
SCHEMBL9069000 0.87 CHRNB2 (0.49) CHRNB2CHRNA4ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL9069331 0.87 CHRNB2 (0.49) CHRNB2CHRNA4ALDH1A1SMN1; SMN2KMT2A
SCHEMBL237015 0.87 CHRNB2 (0.49) CHRNB2CHRNA4ALDH1A1SMN1; SMN2CYP1A2
Desmethylthiamethoxam SCHEMBL6445790 0.84 CHRNB2 (0.40) CHRNB2CHRNA4ALDH1A1LMNAKMT2A
Desmethylthiamethoxam SCHEMBL7173902 0.84 CHRNB2 (0.40) CHRNB2CHRNA4ALDH1A1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0431361-B1 Use of stabilizers for agrochemical compositions BAYER AGROCHEM KK (JP) 1994-02-23 EP claimed
EP-0431362-B1 Stabilized agrochemical compositions BAYER AGROCHEM KK (JP) 1993-11-03 EP claimed
EP-0431361-A1 Use of stabilizers for agrochemical compositions NIHON BAYER AGROCHEM K.K. (JP) 1991-06-12 EP claimed
EP-0431362-A1 Stabilized agrochemical compositions NIHON BAYER AGROCHEM K.K. (JP) 1991-06-12 EP claimed
US-20170112132-A1 PESTICIDAL MIXTURES INCLUDING SPIROHETEROCYCLIC PYRROLIDINE DIONES SYNGENTA PARTICIPATIONS AG (CH) 2017-04-27 US disclosed
US-20170112132-A1 PESTICIDAL MIXTURES INCLUDING SPIROHETEROCYCLIC PYRROLIDINE DIONES SYNGENTA PARTICIPATIONS AG (CH) 2017-04-27 US disclosed
EP-2107871-B1 INSECTICIDAL ACTIVE INGREDIENT COMBINATIONS (FORMONONETINS + INSECTICIDES) PLANT HEALTH CARE INC (US) 2017-04-12 EP disclosed
US-20170071203-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-03-16 US disclosed
US-9560851-B2 Pesticidal mixtures including spiroheterocyclic pyrrolidine diones SYNGENTA PARTICIPATIONS AG (CH) 2017-02-07 US disclosed
US-9560851-B2 Pesticidal mixtures including spiroheterocyclic pyrrolidine diones SYNGENTA PARTICIPATIONS AG (CH) 2017-02-07 US disclosed
EP-2114118-B2 SAFEGUARDING SEED SAFETY OF TREATED SEEDS BAYER CROPSCIENCE AG (DE) 2016-12-14 EP disclosed
US-9210935-B2 Pesticide composition comprising fosetyl-aluminium, propamocarb-HCl and an insecticide active substance BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-15 US disclosed
US-4968695-A NEMATOCIDES, LARVICIDES BAYER AKTIENGESELLSCHAFT (DE) 1990-11-06 US disclosed
US-4956356-A INSECTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1990-09-11 US disclosed
EP-0344500-A1 3-Substituted 1-nitro-2-imino-1,3-diazacycloalkanes BAYER AG (DE) 1989-12-06 EP disclosed
US-4845106-A INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1989-07-04 US disclosed
EP-0292822-A2 Substituted nitroalkenes BAYER AG (DE) 1988-11-30 EP disclosed
EP-0285985-A1 3-Substituted 1-(2-chlorothiazol-5-yl-methyl)-2-nitroimino-1,3-diazacycloalkanes BAYER AG (DE) 1988-10-12 EP disclosed
US-4742060-A 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) 1988-05-03 US disclosed
EP-0192060-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1986-08-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170071203-A1 Active compound combinations having insecticidal properties ACHE, BCHE, DDT CHRNB2 1194/4885CHRNA4 684/4885ALDH1A1 780/4885
US-20170112132-A1 PESTICIDAL MIXTURES INCLUDING SPIROHETEROCYCLIC PYRROLIDINE DIONES DDT, ECH1, PLD1 CHRNB2 2029/4885CHRNA4 2125/4885ALDH1A1 1101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.