Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636899 | 0.86 | CA12 (0.66) | CA12CA1CA2CA9CA7 | |
| SCHEMBL2428794 | 0.85 | CA12 (0.50) | CA12CA1CA2CA9CA7 | |
| SCHEMBL3931674 | 0.85 | OPRM1 (0.61) | CA12CA1CA2CA9CA7 | |
| SCHEMBL3494228 | 0.83 | CA12 (0.49) | CA12CA1CA2CA9CA7 | |
| SCHEMBL23647458 | 0.82 | CA12 (0.50) | CA12CA1CA2CA9CA7 | |
| SCHEMBL28123150 | 0.81 | CA12 (0.47) | CA12CA1CA2CA9CA7 | |
| SCHEMBL23647460 | 0.81 | ALDH1A1 (0.54) | CA12CA1CA2CA9CA7 | |
| SCHEMBL5376588 | 0.81 | CA12 (0.47) | CA12CA1CA2CA9CA7 | |
| SCHEMBL1938611 | 0.80 | RORC (0.48) | CA12CA1CA2CA9OPRM1 | |
| SCHEMBL23210895 | 0.79 | CA12 (0.36) | CA12CA1CA2CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745209-B | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | disclosed |
| WO-2017060873-A1 | SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE | AbbVie S.à.r.l. (LU) | 2017-04-13 | — | — | WO | disclosed |
| WO-2017060874-A1 | N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | ABBVIE S.Á.R.L (LU) | 2017-04-13 | — | — | WO | disclosed |
| CN-106470990-A | pyridazine compounds | 武田药品工业株式会社 | 2017-03-01 | — | — | CN | disclosed |
| CN-105745209-A | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2016-07-06 | — | — | CN | disclosed |
| US-20110230660-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | Method for Preparing a Spiroindoline | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230660-A1 | METHOD FOR PREPARING A SPIROINDOLINE AND A PRECURSOR THEREOF | CCR2, CXCR4, CXCR2 | CA12 4815/4885CA1 3958/4885CA2 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.