Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A13 | Q16696 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL921683 | 0.81 | MEN1 (0.57) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL27854561 | 0.78 | CYP2A13 (0.53) | CYP2A13NPC1RAB9AMETAP2PAX8 | |
| SCHEMBL27922987 | 0.74 | SMN1; SMN2 (0.46) | CYP2A13NPC1RAB9AMETAP2PAX8 | |
| SCHEMBL6179848 | 0.74 | METAP2 (0.37) | NPC1RAB9AMETAP2ALDH1A1MEN1 | |
| SCHEMBL1565830 | 0.73 | SIGMAR1 (0.41) | L3MBTL1HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL14875501 | 0.72 | AOC1 (0.49) | CYP2A13CYP2C9ALOX15HSD17B10HRH3 | |
| SCHEMBL12907967 | 0.72 | SIGMAR1 (0.56) | — | |
| SCHEMBL4105461 | 0.71 | CYP2A13 (1.00) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL31428721 | 0.71 | ALDH1A1 (0.69) | CYP2A13NPC1RAB9AMETAP2PAX8 | |
| SCHEMBL20945444 | 0.71 | SIGMAR1 (0.48) | HRH3ALDH1A1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |