SCHEMBL238274

SCHEMBL238274

C=CC(=O)OC[Si](OCCC)(OCCC)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 5/20 0.46
TSHR P16473 8/20 0.41
HPGD P15428 1/20 0.41
LMNA P02545 1/20 0.40
ALDH1A1 P00352 5/20 0.37
THRA P10827 1/20 0.36
TOP2A P11388 1/20 0.34
TP53 P04637 2/20 0.34
HIF1A Q16665 2/20 0.34
HSD17B10 Q99714 2/20 0.34
CYP3A4 P08684 1/20 0.34
GAA P10253 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
EDNRB P24530 1/20 0.34
EDNRA P25101 1/20 0.34
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
KDM4E B2RXH2 1/20 0.32
GLA P06280 1/20 0.32
CASP1 P29466 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL237184 0.89 THRB (0.44) THRBTSHRHPGDALDH1A1THRA
SCHEMBL1066699 0.88 THRB (0.48) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL237882 0.86 THRB (0.46) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL1063249 0.85 TSHR (0.49) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL7873872 0.84 TSHR (0.48) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL235466 0.82 THRB (0.46) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL27424756 0.82 TSHR (0.49) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL27806783 0.82 TSHR (0.46) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL238285 0.81 TSHR (0.40) THRBTSHRLMNAALDH1A1TOP2A
SCHEMBL27323436 0.79 TSHR (0.42) THRBTSHRHPGDLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9745406-B2 Curable composition CEMEDINE CO., LTD. (JP) 2017-08-29 US disclosed
EP-2412756-B1 CURABLE COMPOSITION CEMEDINE CO LTD (JP) 2016-12-21 EP disclosed
CN-102746467-B Curable composition and process for production of organosilicon compound TOAGOSEI CO LTD 2015-01-14 CN disclosed
US-8829142-B2 Curable composition and process for production of organosilicon compound TOAGOSEI CO., LTD. (JP) 2014-09-09 US disclosed
EP-2270070-B1 CURABLE COMPOSITION, AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND TOAGOSEI CO LTD (JP) 2014-07-30 EP disclosed
EP-2565217-B1 Curable composition and process for production of organosilicon compound TOAGOSEI CO LTD (JP) 2014-05-14 EP disclosed
US-20130149455-A1 CURABLE COMPOSITION AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND TOAGOSEI CO., LTD. (JP) 2013-06-13 US disclosed
EP-2565217-A1 Curable composition and process for production of organosilicon compound TOAGOSEI CO., LTD. (JP) 2013-03-06 EP disclosed
EP-2412756-A1 CURABLE COMPOSITION CEMEDINE CO., LTD. (JP) 2012-02-01 EP disclosed
US-20120004371-A1 CURABLE COMPOSITION CEMEDINE CO., LTD. (JP) 2012-01-05 US disclosed
US-20110071255-A1 CURABLE COMPOSITION AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND TOAGOSEI CO., LTD. (JP) 2011-03-24 US disclosed
EP-2270070-A1 CURABLE COMPOSITION, AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND Toagosei Co., Ltd (JP) 2011-01-05 EP disclosed