SCHEMBL1066699

SCHEMBL1066699

C=CC(=O)OCC[Si](OCCC)(OCCC)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
THRB P10828 5/20 0.48
TSHR P16473 6/20 0.44
HPGD P15428 1/20 0.44
LMNA P02545 2/20 0.39
ALDH1A1 P00352 4/20 0.37
TP53 P04637 2/20 0.37
HIF1A Q16665 2/20 0.37
CYP3A4 P08684 1/20 0.37
HSD17B10 Q99714 1/20 0.37
THRA P10827 1/20 0.36
HCAR2 Q8TDS4 2/20 0.34
TOP2A P11388 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
GAA P10253 1/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
APP P05067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1063249 0.92 TSHR (0.49) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL7873872 0.91 TSHR (0.48) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL1066824 0.90 THRB (0.49) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL27424756 0.89 TSHR (0.49) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL238274 0.88 THRB (0.46) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL9402750 0.85 HCAR2 (0.40) LMNAALDH1A1HCAR2TOP2AAPP
SCHEMBL27323436 0.85 TSHR (0.42) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL1065667 0.85 THRB (0.51) THRBTSHRHPGDALDH1A1TP53
SCHEMBL27449214 0.84 THRB (0.46) THRBTSHRHPGDLMNAALDH1A1
SCHEMBL27806783 0.84 TSHR (0.46) THRBTSHRHPGDLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8829142-B2 Curable composition and process for production of organosilicon compound TOAGOSEI CO., LTD. (JP) 2014-09-09 US disclosed
EP-2270070-B1 CURABLE COMPOSITION, AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND TOAGOSEI CO LTD (JP) 2014-07-30 EP disclosed
EP-2565217-B1 Curable composition and process for production of organosilicon compound TOAGOSEI CO LTD (JP) 2014-05-14 EP disclosed
US-20130149455-A1 CURABLE COMPOSITION AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND TOAGOSEI CO., LTD. (JP) 2013-06-13 US disclosed
EP-2565217-A1 Curable composition and process for production of organosilicon compound TOAGOSEI CO., LTD. (JP) 2013-03-06 EP disclosed
CN-101226329-B Radiation sensitive resin composition, laminated insulating film, micro lens and preparation method thereof JSR CORP 2012-09-05 CN disclosed
US-20110071255-A1 CURABLE COMPOSITION AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND TOAGOSEI CO., LTD. (JP) 2011-03-24 US disclosed
EP-2270070-A1 CURABLE COMPOSITION, AND PROCESS FOR PRODUCTION OF ORGANOSILICON COMPOUND Toagosei Co., Ltd (JP) 2011-01-05 EP disclosed