Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.47 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2383169 | 0.84 | HSD11B1 (0.45) | HSD11B1HSD11B2 | |
| SCHEMBL12303174 | 0.72 | HSD11B1 (0.53) | HSD11B1HSD11B2CCR2 | |
| SCHEMBL13784375 | 0.69 | HSD11B1 (0.52) | HSD11B1HSD11B2 | |
| SCHEMBL5104767 | 0.67 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL13211412 | 0.66 | HSD11B1 (0.43) | HSD11B1HSD11B2 | |
| SCHEMBL4094297 | 0.64 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL2381963 | 0.64 | HSD11B1 (1.00) | HSD11B1HSD11B2 | |
| SCHEMBL10783825 | 0.64 | TSHR (0.41) | HSD11B1HSD11B2CCR2 | |
| SCHEMBL5104628 | 0.62 | HSD11B1 (0.41) | HSD11B1 | |
| SCHEMBL10787187 | 0.62 | TSHR (0.47) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026264-B2 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 | MERCK SHARP AND DOHME CORP. (US) | 2011-09-27 | — | — | US | disclosed |
| US-8026264-B2 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 | MERCK SHARP AND DOHME CORP. (US) | 2011-09-27 | — | — | US | disclosed |
| US-8026264-B2 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 | MERCK SHARP AND DOHME CORP. (US) | 2011-09-27 | — | — | US | disclosed |
| EP-1638947-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-1638947-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-1638947-A4 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-20060258695-A1 | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2006-11-16 | — | — | US | disclosed |
| EP-1638947-A2 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | Merck & Co., Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004106294-A2 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258695-A1 | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885HSD11B2 5/4885CCR2 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.