Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydroxytoluic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.96 |
| ▸ | HPGD | P15428 | 3/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MYC | P01106 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxytoluic Acid SCHEMBL25756 | 0.98 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL8352264 | 0.98 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL29499765 | 0.98 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL28037743 | 0.98 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL25337502 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL31174935 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL30538819 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL622892 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL25338040 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| Hydroxytoluic Acid SCHEMBL11527547 | 0.96 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371609-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO LLC | 2021-12-02 | — | — | US | disclosed |
| EP-3707198-B1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | COVESTRO DEUTSCHLAND AG (DE) | 2021-10-27 | — | — | EP | disclosed |
| EP-3707198-A1 | PLASTIC FILMS WITH REDUCED UV ACTIVITY | Covestro Deutschland AG (DE) | 2020-09-16 | — | — | EP | disclosed |
| EP-3436284-A1 | METHOD FOR THE PARTIAL COLORING OF PLASTIC PARTS | Covestro Deutschland AG (DE) | 2019-02-06 | — | — | EP | disclosed |
| US-10131178-B2 | Layered structure and films for ID documents having improved properties for laser engraving | COVESTRO DEUTSCHLAND AG (DE) | 2018-11-20 | — | — | US | disclosed |
| EP-2820071-B1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | COVESTRO DEUTSCHLAND AG (DE) | 2017-03-22 | — | — | EP | disclosed |
| US-9551975-B2 | Polycarbonate-based security documents and/or documents of value with a hologram in the card body | COVESTRO DEUTSCHLAND AG (DE) | 2017-01-24 | — | — | US | disclosed |
| US-9108357-B2 | Multilayer decorative film | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-18 | — | — | US | disclosed |
| US-20150220056-A1 | POLYCARBONATE-BASED SECURITY DOCUMENTS AND/OR DOCUMENTS OF VALUE WITH A HOLOGRAM IN THE CARD BODY | BAYER MATERIALSCIENCE AG (DE) | 2015-08-06 | — | — | US | disclosed |
| EP-2820071-A1 | PROCESS FOR THE PRODUCTION OF LOW STRESS AND OPTICAL QUALITY FILM FOR USE IN OPTO-ELECTRONIC DEVICES | Bayer Intellectual Property GmbH (DE) | 2015-01-07 | — | — | EP | disclosed |
| US-7250483-B2 | Inhibition of catalytically active impurities in polycarbonate by the melt transesterification process | BAYER MATERIALSCIENCE AG (DE) | 2007-07-31 | — | — | US | disclosed |
| EP-1554333-B1 | METHOD AND APPARATUS TO MAKE HIGH MOLECULAR WEIGHT MELT POLYCARBONATE | GEN ELECTRIC (US) | 2007-04-18 | — | — | EP | disclosed |
| US-7091302-B2 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20060004178-A1 | Inhibition of catalytically active impurities in polycarbonate by the melt transesterification process | COVESTRO DEUTSCHLAND AG (DE) | 2006-01-05 | — | — | US | disclosed |
| CN-1694914-A | Method and apparatus for preparing high molecular weight melt polycarbonate | GEN ELECTRIC (US) | 2005-11-09 | — | — | CN | disclosed |
| US-20050239995-A1 | Process for the preparation of polycarbonate | BAYER MATERIALSCIENCE AG | 2005-10-27 | — | — | US | disclosed |
| EP-1554333-A1 | METHOD AND APPARATUS TO MAKE HIGH MOLECULAR WEIGHT MELT POLYCARBONATE | GENERAL ELECTRIC COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| US-6887969-B2 | Method and apparatus to make high molecular weight melt polycarbonate | GENERAL ELECTRIC COMPANY (US) | 2005-05-03 | — | — | US | disclosed |
| WO-2004033531-A1 | METHOD AND APPARATUS TO MAKE HIGH MOLECULAR WEIGHT MELT POLYCARBONATE | GENERAL ELECTRIC COMPANY (US) | 2004-04-22 | — | — | WO | disclosed |
| US-20040068086-A1 | Method and apparatus to make high molecular weight melt polycarbonate | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2004-04-08 | — | — | US | disclosed |