Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21893293 | 0.86 | HPGDS (0.35) | ALDH1A1GAAHPGD | |
| SCHEMBL23838702 | 0.80 | MAOA (0.35) | KDM4E | |
| SCHEMBL18909543 | 0.69 | KDM4E (0.46) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL19889808 | 0.68 | KDM4E (0.44) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL13977941 | 0.66 | KDM4E (0.46) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL19001629 | 0.66 | KDM4E (0.46) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL23343244 | 0.65 | KDM4E (0.52) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL13977939 | 0.63 | CES2 (0.39) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| SCHEMBL21953560 | 0.63 | KDM4E (0.48) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL4201173 | 0.61 | ALDH1A1 (0.59) | KDM4ESMN1; SMN2RAB9AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230254-B1 | COMPOSITIONS AND METHODS FOR TREATING DISEASES AND CONDITIONS | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2021-09-22 | — | — | EP | disclosed |