Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23818844 | 0.86 | POLRMT (0.35) | POLRMTDOT1L | |
| SCHEMBL23818531 | 0.84 | POLRMT (0.34) | POLRMT | |
| SCHEMBL23844099 | 0.83 | POLRMT (0.37) | POLRMTDOT1L | |
| SCHEMBL27438391 | 0.81 | POLRMT (0.39) | POLRMT | |
| SCHEMBL23844007 | 0.79 | POLRMT (0.44) | POLRMTDOT1L | |
| SCHEMBL20144205 | 0.77 | DOT1L (0.35) | POLRMTDOT1L | |
| SCHEMBL26289321 | 0.77 | POLRMT (0.36) | POLRMTDOT1L | |
| SCHEMBL20960139 | 0.77 | POLRMT (0.45) | POLRMTDOT1L | |
| SCHEMBL27438664 | 0.77 | POLRMT (0.45) | POLRMTDOT1L | |
| SCHEMBL23844011 | 0.77 | DOT1L (0.32) | POLRMTDOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030903-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| US-20210292348-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030903-B2 | Antiviral compounds | EIF2AK2, MAVS, DUT | POLRMT 76/4885DOT1L 653/4885 |
| US-20210292348-A1 | ANTIVIRAL COMPOUNDS | EIF2AK2, MAVS, DUT | POLRMT 76/4885DOT1L 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.