Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23846503 | 0.83 | SMN1; SMN2 (0.71) | ALPLSMN1; SMN2LMNAHTTRECQL | |
| SCHEMBL17980891 | 0.82 | MAPT (0.60) | ALPLSMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL25754817 | 0.82 | NPSR1 (0.62) | ALPLSMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL23833758 | 0.82 | RECQL (0.73) | ALPLSMN1; SMN2LMNARECQLGAA | |
| SCHEMBL23846500 | 0.82 | LMNA (0.73) | ALPLSMN1; SMN2LMNAHTTRECQL | |
| SCHEMBL23847019 | 0.81 | MEN1 (0.61) | ALPLSMN1; SMN2LMNAHTTRECQL | |
| SCHEMBL23847027 | 0.81 | MEN1 (0.59) | ALPLSMN1; SMN2LMNAHTTRECQL | |
| SCHEMBL23846529 | 0.80 | ALPL (0.60) | ALPLSMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL23833737 | 0.79 | MEN1 (0.63) | ALPLSMN1; SMN2LMNAHTTRECQL | |
| SCHEMBL7535714 | 0.78 | SMN1; SMN2 (0.72) | ALPLSMN1; SMN2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188880-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |