Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.58 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.58 |
| ▸ | MGAM | O43451 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23850792 | 0.92 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL23851328 | 0.81 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL23850164 | 0.79 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL31461666 | 0.79 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL3913279 | 0.77 | MAPT (0.72) | RORCALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL5457779 | 0.77 | RAB9A (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL23850168 | 0.75 | RORC (1.00) | RORCALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL31238968 | 0.74 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL23850170 | 0.74 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A | |
| SCHEMBL28632322 | 0.74 | RORC (1.00) | RORCALDH1A1GAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709383-A1 | INVERSE AGONISTS OF RAR RELATED ORPHAN RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2026-03-18 | — | — | EP | claimed |
| US-12390461-B2 | Modulators of RAR-related orphan receptors (RORs) | 11949098 CANADA INC. (CA) | 2025-08-19 | — | — | US | claimed |
| EP-3883929-B1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 CANADA INC (CA) | 2025-06-04 | — | — | EP | claimed |
| WO-2025097247-A1 | METHOD OF TREATMENT OF FIBROSIS WITH INVERSE AGONIST OF RAR RELATED ORPHAN RECEPTORS (RORS) | 11949098 CANADA INC. (CA) | 2025-05-15 | — | — | WO | claimed |
| US-20250073233-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC NUREDCO (CA) | 2025-03-06 | — | — | US | claimed |
| WO-2024229569-A9 | INVERSE AGONISTS OF RAR RELATED ORPHAN RECEPTORS (RORS) | 11949098 CANADA INC. (CA) | 2025-01-30 | — | — | WO | claimed |
| WO-2024229569-A1 | INVERSE AGONISTS OF RAR RELATED ORPHAN RECEPTORS (RORS) | 11949098 CANADA INC. (CA) | 2024-11-14 | — | — | WO | claimed |
| US-20220000864-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC. (CA) | 2022-01-06 | — | — | US | claimed |
| EP-3883929-A1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2021-09-29 | — | — | EP | claimed |
| CN-113166130-A | 4,5,6, 7-tetrahydro-L-benzothiophene modulators of retinoic acid receptor-associated (RAR) orphan nuclear receptors (ROR) | 11949098加拿大股份有限公司 | 2021-07-23 | — | — | CN | claimed |
| US-20260137650-A1 | MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC (CA) | 2026-05-21 | — | — | US | disclosed |
| US-12390461-B2 | Modulators of RAR-related orphan receptors (RORs) | 11949098 CANADA INC. (CA) | 2025-08-19 | — | — | US | disclosed |
| EP-3883929-B1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 CANADA INC (CA) | 2025-06-04 | — | — | EP | disclosed |
| WO-2025097247-A1 | METHOD OF TREATMENT OF FIBROSIS WITH INVERSE AGONIST OF RAR RELATED ORPHAN RECEPTORS (RORS) | 11949098 CANADA INC. (CA) | 2025-05-15 | — | — | WO | disclosed |
| US-20250073233-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC NUREDCO (CA) | 2025-03-06 | — | — | US | disclosed |
| US-20220000864-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | 11949098 CANADA INC. (CA) | 2022-01-06 | — | — | US | disclosed |
| EP-3883929-A1 | 4,5,6,7-TETRAHYDRO-L-BENZOTHIOPHENE MODULATORS OF RETINOIC ACID RECEPTOR RELATED (RAR) ORPHAN NUCLEAR RECEPTORS (RORS) | 11949098 Canada Inc. (CA) | 2021-09-29 | — | — | EP | disclosed |
| CN-113166130-A | 4,5,6, 7-tetrahydro-L-benzothiophene modulators of retinoic acid receptor-associated (RAR) orphan nuclear receptors (ROR) | 11949098加拿大股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260137650-A1 | MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) | RORC, RORB, RORA | RORC 1/4885ALDH1A1 501/4885GAA 4645/4885 |
| US-20220000864-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | RORB, RORC, RORA | RORC 2/4885ALDH1A1 343/4885GAA 3376/4885 |
| US-12390461-B2 | Modulators of RAR-related orphan receptors (RORs) | RORB, RORC, RORA | RORC 2/4885ALDH1A1 343/4885GAA 3376/4885 |
| US-20250073233-A1 | MODULATORS OF RAR-RELATED ORPHAN RECEPTORS (RORs) | RORB, RORC, RORA | RORC 2/4885ALDH1A1 341/4885GAA 3110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.