Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.64 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922008 | 0.92 | CHRM4 (0.59) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL28351668 | 0.92 | PRMT5 (0.60) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL2025839 | 0.88 | PDE4B (0.53) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL23040449 | 0.81 | LMNA (0.49) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL313776 | 0.81 | PRMT5 (0.64) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL21138877 | 0.81 | ALDH1A1 (0.57) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL9172873 | 0.81 | CHRM4 (0.47) | PRMT5WDR77ALDH1A1RAB9ALMNA | |
| SCHEMBL22659030 | 0.80 | PDE4B (0.53) | PRMT5WDR77LMNAPOLBPDE4B | |
| SCHEMBL30711534 | 0.80 | CHRM4 (0.53) | PRMT5ALDH1A1RAB9ALMNAMAPT | |
| SCHEMBL2132155 | 0.80 | SMN1; SMN2 (0.66) | ALDH1A1RAB9ALMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001863-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007119463-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-10-25 | — | — | WO | disclosed |