SCHEMBL23853822

SCHEMBL23853822

CCOC(=O)c1cc2c(n1Cc1cccc(C)c1)C(=O)CCC2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
KMT2A Q03164 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
MEN1 O00255 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.45
HPGD P15428 2/20 0.45
MAPT P10636 4/20 0.43
THRB P10828 2/20 0.43
NOD2 Q9HC29 1/20 0.43
NOD1 Q9Y239 1/20 0.43
CFTR P13569 2/20 0.42
F10 P00742 2/20 0.42
POLB P06746 2/20 0.42
TSHR P16473 2/20 0.42
ATM Q13315 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
KDM4E B2RXH2 3/20 0.41
TP53 P04637 2/20 0.41
GAA P10253 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31681751 1.00 ALDH1A1 (0.47) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL6115173 0.90 TSHR (0.52) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL18250041 0.88 MAPT (0.52) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL1160587 0.88 NOD2 (0.54) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL31681755 0.88 ALDH1A1 (0.57) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL31681757 0.87 NOD2 (0.55) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL23854245 0.87 ALDH1A1 (0.44) ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2
SCHEMBL18250051 0.87 MAPT (0.46) ALDH1A1KMT2AL3MBTL1MEN1HPGD
SCHEMBL23853955 0.86 NOD2 (0.42) ALDH1A1L3MBTL1SMN1; SMN2HPGDMAPT
SCHEMBL31681758 0.86 NOD2 (0.42) ALDH1A1L3MBTL1SMN1; SMN2HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3883931-A1 HETEROCYCLIC COMPOUNDS AND MEDICAL USE THEREOF Fondazione Telethon (IT) 2021-09-29 EP disclosed