Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16088642 | 0.88 | PLK1 (0.56) | ITGB1ITGA4TRPV1TP53GAA | |
| SCHEMBL16088657 | 0.83 | PLK1 (0.58) | ITGB1ITGA4TRPV1TP53GAA | |
| SCHEMBL7190666 | 0.81 | TRPV1 (0.61) | TRPV1TP53GAAPOLBNPC1 | |
| SCHEMBL23864295 | 0.80 | POLB (0.46) | TRPV1TP53GAAPOLBNPC1 | |
| SCHEMBL7604301 | 0.78 | NPC1 (0.52) | TRPV1TP53GAAPOLBPLK1 | |
| SCHEMBL23864567 | 0.78 | POLB (0.50) | TRPV1TP53GAAPOLBNPC1 | |
| SCHEMBL16127933 | 0.77 | ITGB1 (0.52) | ITGB1ITGA4PLK1ALOX15KLKB1 | |
| SCHEMBL23864564 | 0.77 | NPC1 (0.50) | TRPV1TP53GAAPOLBNPC1 | |
| SCHEMBL7120573 | 0.75 | TP53 (0.55) | TRPV1TP53GAAPOLBNPC1 | |
| SCHEMBL13689999 | 0.75 | TYK2 (0.56) | ITGB1ITGA4SMN1; SMN2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968330-B1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | SCRIPPS RESEARCH INST (US) | 2021-09-29 | — | — | EP | disclosed |