Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.56 |
| ▸ | JAK2 | O60674 | 9/20 | 0.56 |
| ▸ | JAK1 | P23458 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8278654 | 0.90 | TYK2 (0.60) | TYK2JAK2JAK1SMN1; SMN2TAS1R3 | |
| SCHEMBL28729711 | 0.77 | CYP1A2 (0.53) | TYK2JAK2JAK1SMN1; SMN2CYP3A4 | |
| SCHEMBL8278422 | 0.76 | MAPT (0.63) | TYK2JAK2SMN1; SMN2KMT2A | |
| SCHEMBL13690000 | 0.75 | L3MBTL1 (0.55) | SMN1; SMN2KMT2A | |
| SCHEMBL23864512 | 0.75 | ITGB1 (0.52) | SMN1; SMN2TAS1R3TAS1R1TAS1R2HPGD | |
| SCHEMBL13689807 | 0.74 | ALDH1A1 (0.48) | TYK2JAK2JAK1SMN1; SMN2CYP3A4 | |
| SCHEMBL20275216 | 0.74 | ALDH1A1 (0.46) | TYK2JAK2JAK1HPGD | |
| SCHEMBL13058075 | 0.74 | TYK2 (0.61) | TYK2JAK2JAK1SMN1; SMN2TAS1R3 | |
| SCHEMBL13689804 | 0.74 | ALDH1A1 (0.61) | SMN1; SMN2KMT2A | |
| SCHEMBL95630 | 0.73 | TYK2 (0.65) | TYK2JAK2JAK1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595399-B2 | Tyrosine derivatives | GENENTECH, INC. (US) | 2009-09-29 | — | — | US | disclosed |