Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.74 |
| ▸ | MAPT | P10636 | 7/20 | 0.74 |
| ▸ | GAA | P10253 | 6/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 2/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25751659 | 0.84 | KDM4E (0.58) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL10462854 | 0.82 | KDM4E (0.57) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL18121487 | 0.82 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL31019418 | 0.80 | KDM4E (0.66) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL5220303 | 0.80 | KDM4E (0.66) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL5392425 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL13684477 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL9264953 | 0.75 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL18932679 | 0.75 | NR4A2 (0.67) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL28746471 | 0.75 | KDM4E (0.82) | ALDH1A1KDM4EMAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210299107-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210299107-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | AIFM2, GPX1, SLC7A11 | ALDH1A1 2287/4885KDM4E 3253/4885MAPT 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.