Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.57 |
| ▸ | TUBB | P07437 | 5/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538872 | 0.88 | KDM4E (0.70) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL13758172 | 0.85 | ALDH1A1 (0.76) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL23873802 | 0.84 | ALDH1A1 (0.74) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL21465510 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL3253095 | 0.83 | KDM4E (0.56) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL6308065 | 0.82 | KDM4E (0.58) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL21465557 | 0.82 | TUBB4A (0.65) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL31219205 | 0.81 | MAP2 (0.66) | KDM4EALDH1A1MAP2 | |
| SCHEMBL4332943 | 0.81 | MAP2 (0.61) | KDM4EALDH1A1MEN1KMT2AMAP2 | |
| SCHEMBL5402454 | 0.80 | ALOX15 (0.60) | KDM4EALDH1A1HPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116390-A1 | PYRIMIDINE-2(1H)-ONE-FUSED BICYCLIC COMPOUND HAVING MAT2A INHIBITORY ACTIVITY AND USE THEREOF | 上海海和药物研究开发股份有限公司 | 2023-06-29 | — | — | WO | disclosed |