Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29505307 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2AGAAHPGD | |
| SCHEMBL30378346 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2AGAAHPGD | |
| Formamide SCHEMBL28688411 | 0.91 | HSD11B1 (0.44) | ALDH1A1KDM4EKMT2AGAAHPGD | |
| SCHEMBL5341226 | 0.89 | DPP4 (0.43) | ALDH1A1KDM4EKMT2AGAAHPGD | |
| SCHEMBL26972607 | 0.86 | KDM4E (0.43) | ALDH1A1KDM4EKMT2AGAAGRIN2B | |
| SCHEMBL23875353 | 0.83 | PLD1 (0.52) | ALDH1A1KDM4EHPGDGRIN2BPLD1 | |
| SCHEMBL23860310 | 0.80 | CHI3L1 (0.46) | ALDH1A1KDM4EHPGDGRIN2BPLD1 | |
| SCHEMBL23875357 | 0.80 | CHI3L1 (0.46) | ALDH1A1KDM4EHPGDGRIN2BPLD1 | |
| SCHEMBL29991351 | 0.80 | GRIN2B (0.49) | ALDH1A1KDM4EGRIN2BPLD1GRM1 | |
| SCHEMBL22837869 | 0.79 | HSD11B1 (0.50) | ALDH1A1KDM4EGRIN2BPLD1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194878-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |