Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.42 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.42 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29505307 | 0.86 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTGRIN2BGAA | |
| SCHEMBL30378346 | 0.86 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTGRIN2BGAA | |
| SCHEMBL23875355 | 0.86 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTGRIN2BGAA | |
| SCHEMBL26972635 | 0.82 | LRRK2 (0.39) | KDM4EALDH1A1MAPTGAAGRM1 | |
| SCHEMBL5341226 | 0.79 | DPP4 (0.43) | KDM4EALDH1A1MAPTGRIN2BGAA | |
| Formamide SCHEMBL28688411 | 0.78 | HSD11B1 (0.44) | KDM4EALDH1A1MAPTGRIN2BGAA | |
| SCHEMBL23875674 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1MAPTGRIN2BHSD17B10 | |
| SCHEMBL20204378 | 0.76 | GRM2 (0.42) | KDM4EALDH1A1MAPTGAAKCNH2 | |
| SCHEMBL26974647 | 0.76 | LRRK2 (0.36) | KDM4EALDH1A1GAACHI3L1KCNH2 | |
| SCHEMBL23875357 | 0.75 | CHI3L1 (0.46) | KDM4EALDH1A1MAPTGRIN2BCHI3L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858940-B2 | Selective modulators of mutant LRRK2 proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858940-B2 | Selective modulators of mutant LRRK2 proteolysis and associated methods of use | LRRK2, ADRM1, CRBN | KDM4E 1434/4885ALDH1A1 4021/4885MAPT 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.