SCHEMBL23877565

SCHEMBL23877565

O=C(NC12CC(C(F)(F)F)(C1)C2)c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1cccnc1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 7/20 0.59
▸ USP8 P40818 7/20 0.59
▸ KMT2A Q03164 2/20 0.50
▸ TSHR P16473 1/20 0.45
▸ ACLY P53396 3/20 0.44
▸ NAMPT P43490 3/20 0.43
▸ CKS1B P61024 1/20 0.42
▸ SKP2 Q13309 1/20 0.42
▸ KDM1A O60341 1/20 0.42
▸ MCL1 Q07820 1/20 0.41
▸ USP36 Q9P275 1/20 0.41
▸ MEN1 O00255 1/20 0.40
▸ GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30547616 1.00 USP2 (0.59) USP2USP8KMT2ATSHRACLY
SCHEMBL23877484 0.88 ACLY (0.52) USP2USP8KMT2AACLYKDM1A
SCHEMBL30547620 0.88 ACLY (0.52) USP2USP8KMT2AACLYKDM1A
SCHEMBL30547580 0.83 USP2 (0.50) USP2USP8ACLYKDM1AMCL1
SCHEMBL23879636 0.83 KDM1A (0.50) USP2USP8KMT2AACLYKDM1A
SCHEMBL23877472 0.83 KDM1A (0.50) USP2USP8ACLYKDM1AUSP36
SCHEMBL31046884 0.83 KDM1A (0.50) USP2USP8ACLYKDM1AUSP36
SCHEMBL23877433 0.82 KDM1A (0.49) USP2USP8ACLYKDM1AUSP36
SCHEMBL23141234 0.82 KDM1A (0.47) USP2USP8KMT2AACLYKDM1A
SCHEMBL23877599 0.82 KDM1A (0.49) USP2USP8ACLYKDM1AUSP36

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 — — US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 — — US disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 — — US disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885KMT2A 1234/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885KMT2A 1234/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 USP2 3926/4885USP8 3201/4885KMT2A 2071/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885KMT2A 1234/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885KMT2A 1234/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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