SCHEMBL23877642

SCHEMBL23877642

CC(C)(C)S(=O)(=O)Nc1ccc(Br)cc1C(=O)NC12CC(c3ccccc3)(C1)C2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.43
▸ CNR2 P34972 1/20 0.38
▸ METAP2 P50579 3/20 0.38
▸ MAPT P10636 2/20 0.36
▸ SLC10A6 Q3KNW5 2/20 0.35
▸ SLC10A2 Q12908 1/20 0.35
▸ SLC10A1 Q14973 1/20 0.35
▸ PTGFR P43088 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ KDM1A O60341 1/20 0.34
▸ BCL2L1 Q07817 1/20 0.34
▸ MCL1 Q07820 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ GAA P10253 1/20 0.33
▸ THRB P10828 1/20 0.33
▸ GPR27 Q9NS67 1/20 0.32
▸ POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23877460 0.88 KCNA5 (0.41) —
SCHEMBL30547598 0.88 KCNA5 (0.41) —
SCHEMBL23877476 0.86 TBXA2R (0.35) KMT2AMCL1GPR27
SCHEMBL23877569 0.83 CNR2 (0.39) ALDH1A1CNR2METAP2SLC10A6SLC10A2
SCHEMBL31046860 0.83 CNR2 (0.39) ALDH1A1CNR2METAP2SLC10A6SLC10A2
SCHEMBL26188686 0.80 ALDH1A1 (0.40) ALDH1A1CNR2METAP2MAPTSLC10A6
SCHEMBL23877551 0.80 ALDH1A1 (0.48) ALDH1A1CNR2PTGFRMEN1KMT2A
SCHEMBL23877436 0.80 KMT2A (0.36) KMT2AMCL1GPR27
SCHEMBL31046897 0.79 BCAT2 (0.39) ALDH1A1CNR2MAPTPTGFRKMT2A
SCHEMBL23141230 0.75 METAP2 (0.60) ALDH1A1METAP2MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 — — US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 — — US disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 — — US disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B ALDH1A1 245/4885CNR2 240/4885METAP2 2660/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B ALDH1A1 245/4885CNR2 240/4885METAP2 2660/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 ALDH1A1 1507/4885CNR2 154/4885METAP2 3626/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B ALDH1A1 245/4885CNR2 240/4885METAP2 2660/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B ALDH1A1 245/4885CNR2 240/4885METAP2 2660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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