Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.62 |
| ▸ | KDR | P35968 | 7/20 | 0.62 |
| ▸ | MET | P08581 | 7/20 | 0.61 |
| ▸ | AXL | P30530 | 7/20 | 0.61 |
| ▸ | MERTK | Q12866 | 3/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | HCK | P08631 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23880322 | 0.81 | PDGFRA (0.60) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL7487173 | 0.79 | FGFR2 (0.76) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL8552659 | 0.79 | PDGFRA (0.67) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL29883010 | 0.79 | MET (0.66) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL372017 | 0.79 | MET (0.66) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL901281 | 0.78 | PDGFRA (0.68) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL16061581 | 0.77 | MET (0.64) | PDGFRAKDRMETAXLMERTK | |
| Cabozantinib SCHEMBL18095042 | 0.77 | AXL (0.98) | KDRMETAXLMERTKKIT | |
| SCHEMBL7479859 | 0.77 | PDGFRA (1.00) | PDGFRAKDRMETAXLMERTK | |
| SCHEMBL410634 | 0.77 | MET (0.58) | PDGFRAKDRMETAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313048-A1 | PROCESS FOR PREPARATION OF CABOZANTINIB | Biocon Limited (IN) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022201079-A1 | PROCESS FOR PREPARATION OF CABOZANTINIB | BIOCON LIMITED (IN) | 2022-09-29 | — | — | WO | disclosed |