Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 7/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | MET | P08581 | 3/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742894 | 0.87 | MET (0.70) | PDGFRAKDRAURKBFLT3MET | |
| SCHEMBL29972991 | 0.87 | MET (0.70) | PDGFRAKDRAURKBFLT3MET | |
| SCHEMBL12807168 | 0.87 | MET (0.70) | PDGFRAKDRAURKBFLT3MET | |
| SCHEMBL29995716 | 0.81 | AXL (0.72) | KDRAURKBFLT3METAURKA | |
| SCHEMBL23880322 | 0.80 | PDGFRA (0.60) | PDGFRAPDGFRBKDRAURKBFLT3 | |
| SCHEMBL28637610 | 0.79 | AXL (0.74) | KDRAURKBFLT3METAURKA | |
| SCHEMBL23923068 | 0.79 | PDGFRA (0.69) | PDGFRAPDGFRBKDRAURKBMET | |
| SCHEMBL3794599 | 0.79 | FGFR2 (0.69) | PDGFRAPDGFRBKDRAURKBMET | |
| SCHEMBL16061949 | 0.78 | KDR (0.56) | PDGFRAKDRAURKBFLT3MET | |
| SCHEMBL30526378 | 0.77 | PDGFRA (0.67) | PDGFRAPDGFRBKDRFGFR2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110981798-A | Antineoplastic drug cabozantinib impurity, preparation method and application thereof | 乐普药业股份有限公司 | 2020-04-10 | — | — | CN | disclosed |