Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.51 |
| ▸ | CA1 | P00915 | 5/20 | 0.51 |
| ▸ | FURIN | P09958 | 8/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946400 | 0.98 | CA2 (0.53) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL20158426 | 0.92 | CA2 (0.46) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL17902993 | 0.92 | CA2 (0.46) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL14012279 | 0.92 | CA2 (0.46) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL12283259 | 0.92 | CA2 (0.46) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL13436625 | 0.92 | CA2 (0.46) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL17541357 | 0.89 | CA2 (0.47) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL17541356 | 0.89 | CA2 (0.47) | CA2CA1FURINMMP1MMP3 | |
| SCHEMBL23900676 | 0.89 | SIRT5 (0.43) | CA2CA1FURINSIRT5BACE1 | |
| SCHEMBL20173512 | 0.89 | CA1 (0.45) | CA2CA1FURINMMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11712480-B2 | Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates | PFIZER INC. (US) | 2023-08-01 | — | — | US | disclosed |
| US-20210308276-A1 | HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2021-10-07 | — | — | US | disclosed |
| US-20210308276-A1 | HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11712480-B2 | Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates | SULT1E1, SULT2A1, STS | CA2 4775/4885CA1 4476/4885FURIN 557/4885 |
| US-20210308276-A1 | HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES | SULT1E1, FCGRT, SULT2A1 | CA2 4843/4885CA1 4715/4885FURIN 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.