Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23899054 | 0.85 | CA12 (0.41) | ALDH1A1LMNACA1CA2CA9 | |
| SCHEMBL23898997 | 0.77 | SIGMAR1 (0.34) | ALDH1A1LMNASMN1; SMN2SPRGAA | |
| SCHEMBL23899027 | 0.76 | SIGMAR1 (0.36) | ALDH1A1LMNASMN1; SMN2HPGDMEN1 | |
| SCHEMBL27166849 | 0.75 | CYP2C19 (0.39) | ALDH1A1LMNASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL25414591 | 0.75 | NOTUM (0.44) | ALDH1A1LMNAHPGDMEN1KMT2A | |
| SCHEMBL23899152 | 0.74 | SIGMAR1 (0.34) | — | |
| SCHEMBL19207529 | 0.74 | ALDH1A1 (0.55) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL17591926 | 0.72 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL4532875 | 0.72 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL2515677 | 0.72 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4613745-A2 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | Gilead Sciences, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| US-12365666-B2 | Process for preparing a Cot inhibitor compound | GILEAD SCIENCES, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| EP-4126862-B1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES INC (US) | 2025-05-21 | — | — | EP | disclosed |
| CN-119390681-A | Process for preparing COT inhibitor compounds | 吉利德科学公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-115397824-B | Process for preparing COT inhibitor compounds | 吉利德科学公司 | 2024-10-22 | — | — | CN | disclosed |
| US-20240199579-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. | 2024-06-20 | — | — | US | disclosed |
| US-11845737-B2 | Process for preparing a Cot inhibitor compound | GILEAD SCIENCES, INC. (US) | 2023-12-19 | — | — | US | disclosed |
| EP-4126862-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. (US) | 2023-02-08 | — | — | EP | disclosed |
| US-20220380340-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. | 2022-12-01 | — | — | US | disclosed |
| WO-2021202688-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | GILEAD SCIENCES, INC. (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11845737-B2 | Process for preparing a Cot inhibitor compound | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885SMN1; SMN2 4634/4885 |
| US-20220380340-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885SMN1; SMN2 4634/4885 |
| US-20240199579-A1 | PROCESS FOR PREPARING A COT INHIBITOR COMPOUND | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885SMN1; SMN2 4634/4885 |
| US-12365666-B2 | Process for preparing a Cot inhibitor compound | TPO, TFPI, TFPI2 | ALDH1A1 1859/4885LMNA 3342/4885SMN1; SMN2 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.